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1

Metabolism considerations for kinase inhibitors in cancer treatment

Duckett, Derek R, Cameron, Michael D

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2010

Language:

english

File:

PDF, 421 KB

english, 2010

2

Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer

Quereda, Victor, Bayle, Simon, Vena, Francesca, Frydman, Sylvia M., Monastyrskyi, Andrii, Roush, William R., Duckett, Derek R.

Journal:

Year:

2019

Language:

english

File:

PDF, 5.85 MB

english, 2019

3

3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors

Rong Jiang, Derek Duckett, Weiming Chen, Jeff Habel, Yuan Yuan Ling, Philip LoGrasso, Theodore M. Kamenecka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 232 KB

english, 2007

4

Chroman-3-amides as potent Rho kinase inhibitors

Yen Ting Chen, Thomas D. Bannister, Amiee Weiser, Evelyn Griffin, Li Lin, Claudia Ruiz, Michael D. Cameron, Stephan Schürer, Derek Duckett, Thomas Schröter, Philip LoGrasso, Yangbo Feng

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 426 KB

english, 2008

5

Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors

Youseung Shin, Weiming Chen, Jeff Habel, Derek Duckett, Yuan Yuan Ling, Marcel Koenig, Yuanjun He, Tomas Vojkovsky, Philip LoGrasso, Theodore M. Kamenecka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 493 KB

english, 2009

6

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors

Yan Yin, Li Lin, Claudia Ruiz, Michael D. Cameron, Jennifer Pocas, Wayne Grant, Thomas Schröter, Weimin Chen, Derek Duckett, Stephan Schürer, Philip LoGrasso, Yangbo Feng

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 365 KB

english, 2009

7

Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors

Romain Noël, Youseung Shin, Xinyi Song, Yuanjun He, Marcel Koenig, Weimin Chen, Yuan Yuan Ling, Li Lin, Claudia H. Ruiz, Phil LoGrasso, Michael D. Cameron, Derek R. Duckett, Theodore M. Kamenecka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 623 KB

english, 2011

8

Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) Inhibitors

Yuanjun He, Theodore M. Kamenecka, Youseung Shin, Xinyi Song, Rong Jiang, Romain Noel, Derek Duckett, Weimin Chen, Yuan Yuan Ling, Michael D. Cameron, Li Lin, Susan Khan, Marcel Koenig, Philip V. LoGr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 2.52 MB

english, 2011

9

Nucleic acid structure and recognition

Derek R. Duckett, Alastair I.H. Murchie, Robert M. Clegg, Gurminder S. Bassi, Marie-Josèphe E. Giraud-Panis, David M.J. Lilley

Journal:

Biophysical Chemistry

Year:

1997

Language:

english

File:

PDF, 969 KB

english, 1997

10

Fluorescence energy transfer shows that the four-way DNA junction is a right-handed cross of antiparallel molecules

Murchie, Alastair I. H., Clegg, Robert M., Krtzing, Eberhard von, Duckett, Derek R., Diekmann, Stephan, Lilley, David M. J.

Journal:

Year:

1989

File:

PDF, 466 KB

1989

11

Association of Conventional and Exertional Coronary Heart Disease Risk Factors in 5,000 Apparently Healthy Men

Bruce Davies, William D. Ashton, Derek J. Rowlands, Mahmoud El-Sayed, Philip C. Wallace, Ken Duckett, John Coley, Anne M. Daggett

Journal:

Clinical Cardiology

Year:

1996

Language:

english

File:

PDF, 630 KB

english, 1996

12

Synthesis and SAR of 2-Phenoxypyridines as novel c-Jun N-terminal kinase inhibitors

Xinyi Song, Weimin Chen, Li Lin, Claudia H. Ruiz, Michael D. Cameron, Derek R. Duckett, Theodore M. Kamenecka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 528 KB

english, 2011

13

Nicotine-mediated signals modulate cell death and survival of T lymphocytes

Silvia C.S. Oloris, Ashley A. Frazer-Abel, Cristan M. Jubala, Susan P. Fosmire, Karen M. Helm, Sally R. Robinson, Derek M. Korpela, Megan M. Duckett, Shairaz Baksh, Jaime F. Modiano

Journal:

Toxicology and Applied Pharmacology

Year:

2010

Language:

english

File:

PDF, 1.10 MB

english, 2010

14

The structure of DNA junctions and their interaction with enzymes

Derek R. DUCKETT, Alastair I. H. MURCHIE, Anamitra BHATTACHARYYA, Robert M. CLEGG, Stephan DIEKMANN, Eberhard von KITZING, David M. J. LILLEY

Journal:

Year:

1992

Language:

english

File:

PDF, 1.33 MB

english, 1992

15

Small Molecule c-jun-N-Terminal Kinase Inhibitors Protect Dopaminergic Neurons in a Model of Parkinson’s Disease

Chambers, Jeremy W., Pachori, Alok, Howard, Shannon, Ganno, Michelle, Hansen, Donald, Kamenecka, Ted, Song, Xinyi, Duckett, Derek, Chen, Weimin, Ling, Yuan Yuan

Journal:

ACS Chemical Neuroscience

Year:

2011

Language:

english

File:

PDF, 2.31 MB

english, 2011

16

Binding of the Junction-resolving Enzyme Bacteriophage T7 Endonuclease I to DNA: Separation of Binding and Catalysis by Mutation

Derek R. Duckett, Marie-Josèphe E. Giraud Panis, David M.J. Lilley

Journal:

Journal of Molecular Biology

Year:

1995

Language:

english

File:

PDF, 558 KB

english, 1995

17

Structure of Four-way DNA Junctions containing a Nick in One Strand

J.Richard G. Pöhler, Derek R. Duckett, David M.J. Lilley

Journal:

Journal of Molecular Biology

Year:

1994

File:

PDF, 1.11 MB

1994

18

The Modular Character of a DNA Junction-resolving Enzyme: A Zinc-binding Motif in Bacteriophage T4 Endonuclease VII

Marie-Josèphe E. Giraud-Panis, Derek R. Duckett, David M.J. Lilley

Journal:

Journal of Molecular Biology

Year:

1995

Language:

english

File:

PDF, 918 KB

english, 1995

19

Effects of base mismatches on the structure of the four-way DNA junction

Derek R. Duckett, David M.J. Lilley

Journal:

Journal of Molecular Biology

Year:

1991

Language:

english

File:

PDF, 8.20 MB

english, 1991

20

Synthesis of Potent Bicyclic Bisarylimidazole c-Jun N-Terminal Kinase Inhibitors by Catalytic C−H Bond Activation

Rech, Jason C., Yato, Michihisa, Duckett, Derek, Ember, Brian, LoGrasso, Philip V., Bergman, Robert G., Ellman, Jonathan A.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 41 KB

english, 2007

21

The structure of the holliday junction, and its resolution

Duckett, Derek R., Murchie, Alastair I.H., Diekmann, Stephen, von Kitzing, Eberhard, Kemper, BÃ¶rries, Lilley, David M.J.

Journal:

Year:

1988

Language:

english

File:

PDF, 3.31 MB

english, 1988

22

Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors

Kamenecka, Ted, Jiang, Rong, Song, Xinyi, Duckett, Derek, Chen, Weimin, Ling, Yuan Yuan, Habel, Jeff, Laughlin, John D., Chambers, Jeremy, Figuera-Losada, Mariana, Cameron, Michael D., Lin, Li, Ruiz,

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 3.78 MB

english, 2010

23

Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors

He, Yuanjun, Duckett, Derek, Chen, Weimin, Ling, Yuan Yuan, Cameron, Michael D., Lin, Li, Ruiz, Claudia H., LoGrasso, Philip V., Kamenecka, Theodore M., Koenig, Marcel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.73 MB

english, 2014

24

Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors

Jiang, Rong, Frackowiak, Bozena, Shin, Youseung, Song, Xinyi, Chen, Weimin, Lin, Li, Cameron, Michael D., Duckett, Derek R., Kamenecka, Theodore M.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.53 MB

english, 2013

25

Stress-induced nuclear import of apoptosis signal-regulating kinase 1 is mediated by karyopherin α2/β1 heterodimer

Sturchler, Emmanuel, Feurstein, Daniel, Chen, Weimin, McDonald, Patricia, Duckett, Derek

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2013

Language:

english

File:

PDF, 1.30 MB

english, 2013

26

Human MutSα Recognizes Damaged DNA Base Pairs Containing O6-Methylguanine, O4-Methylthymine, or the Cisplatin-d(GpG) Adduct

Derek R. Duckett, James T. Drummond, Alastair I. H. Murchie, Joyce T. Reardon, Aziz Sancar, David M. J. Lilley and Paul Modrich

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 965 KB

english, 1996

27

hMutSα - and hMutLα -Dependent Phosphorylation of p53 in Response to DNA Methylator Damage

Derek R. Duckett, S. Maynard Bronstein, Yoichi Taya and Paul Modrich

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.10 MB

english, 1999

28

DNA Repair and Recombination || Structure of the Four-Way DNA Junction and Its Interaction with Proteins

Derek R. Duckett, Alastair I. H. Murchie, Marie-Josephe E. Giraud-Panis, J. Richard Pohler and David M. J. Lilley

Journal:

Philosophical Transactions Biological Sciences

Year:

1995

Language:

english

File:

PDF, 2.16 MB

english, 1995

29

Mechanism of Oxidative Stress-Induced ASK1-Catalyzed MKK6 Phosphorylation

Sturchler, Emmanuel, Feurstein, Daniel, McDonald, Patricia, Duckett, Derek

Journal:

Year:

2010

Language:

english

File:

PDF, 2.38 MB

english, 2010

30

Identification of SR3335 (ML-176): A Synthetic RORα Selective Inverse Agonist

Kumar, Naresh, Kojetin, Douglas J., Solt, Laura A., Kumar, K. Ganesh, Nuhant, Philippe, Duckett, Derek R., Cameron, Michael D., Butler, Andrew A., Roush, William R., Griffin, Patrick R., Burris, Thoma

Journal:

ACS Chemical Biology

Year:

2011

Language:

english

File:

PDF, 1.39 MB

english, 2011

31

Corrections to Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors

Kamenecka, Ted, Jiang, Rong, Song, Xinyi, Duckett, Derek, Chen, Weimin, Ling, Yuan Yuan, Habel, Jeff, Laughlin, John D., Chambers, Jeremy, Figuera-Losada, Mariana, Cameron, Michael D., Lin, Li, Ruiz,

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 542 KB

english, 2010

32

Development of an HTS-Compatible Assay for the Discovery of ASK1 Signalosome Inhibitors Using AlphaScreen Technology

Sturchler, Emmanuel, Chen, Weimin, Spicer, Timothy, Hodder, Peter, McDonald, Patricia, Duckett, Derek

Journal:

Assay and Drug Development Technologies

Year:

2014

Language:

english

File:

PDF, 593 KB

english, 2014

33

A Predictive Nuclear Translocation Assay for Spliced X-Box–Binding Protein 1 Identifies Compounds with Known Organ Toxicities

Hahmann, Christa, Weiser, Amiee, Duckett, Derek, Schroeter, Thomas

Journal:

Assay and Drug Development Technologies

Year:

2011

Language:

english

File:

PDF, 488 KB

english, 2011

34

Structures of bulged three-way DNA junctions

Welch, Jonathan B., Duckett, Derek R., Lilley, David M.J.

Journal:

Nucleic Acids Research

Year:

1993

Language:

english

File:

PDF, 3.41 MB

english, 1993

35

Design of a small molecule against an oncogenic noncoding RNA

Velagapudi, Sai Pradeep, Cameron, Michael D., Haga, Christopher L., Rosenberg, Laura H., Lafitte, Marie, Duckett, Derek R., Phinney, Donald G., Disney, Matthew D.

Journal:

Proceedings of the National Academy of Sciences

Year:

2016

Language:

english

File:

PDF, 1.17 MB

english, 2016

36

Gel electrophoretic analysis of the structure of nucleic acids

Lilley, David M. J., Bhattacharyya, Anamitra, McAteer, Sean P., Duckett, Derek R.

Journal:

Biochemical Society Transactions

Year:

1993

Language:

english

File:

PDF, 575 KB

english, 1993

37

In Silico HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors

Wood, Spencer D., Grant, Wayne, Adrados, Isabel, Choi, Jun Yong, Alburger, James M., Duckett, Derek R., Roush, William R.

Journal:

ACS Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 1.81 MB

english, 2017

38

Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors

Monastyrskyi, Andrii, Bayle, Simon, Quereda, Victor, Grant, Wayne, Cameron, Michael, Duckett, Derek, Roush, William

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 1.89 MB

english, 2017

39

Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer

Monastyrskyi, Andrii, Nilchan, Napon, Quereda, Victor, Noguchi, Yoshihiko, Ruiz, Claudia, Grant, Wayne, Cameron, Michael, Duckett, Derek, Roush, William

Journal:

Bioorganic & Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 4.87 MB

english, 2017

40

A Cytotoxic Three-Dimensional-Spheroid, High-Throughput Assay Using Patient-Derived Glioma Stem Cells

Quereda, Victor, Hou, Shurong, Madoux, Franck, Scampavia, Louis, Spicer, Timothy P., Duckett, Derek

Journal:

Year:

2018

Language:

english

File:

PDF, 1.21 MB

english, 2018

41

βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1

Nieto, Ainhoa, Hara, Makoto R., Quereda, Victor, Grant, Wayne, Saunders, Vanessa, Xiao, Kunhong, McDonald, Patricia H., Duckett, Derek R.

Journal:

Cell Death & Differentiation

Year:

2019

Language:

english

File:

PDF, 2.84 MB

english, 2019

42

βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1

Nieto, Ainhoa, Hara, Makoto R., Quereda, Victor, Grant, Wayne, Saunders, Vanessa, Xiao, Kunhong, McDonald, Patricia H., Duckett, Derek R.

Journal:

Cell Death & Differentiation

Year:

2019

File:

PDF, 2.84 MB

2019

43

Autophagy is inhibited by ubiquitin ligase activity in the nervous system

Crawley, Oliver, Opperman, Karla J., Desbois, Muriel, Adrados, Isabel, Borgen, Melissa A., Giles, Andrew C., Duckett, Derek R., Grill, Brock

Journal:

Nature Communications

Year:

2019

Language:

english

File:

PDF, 4.49 MB

english, 2019

44

Global structure of four-way RNA junctions studied using fluorescence resonance energy transfer

WALTER, FRANK, MURCHIE, ALASTAIR I.H., DUCKETT, DEREK R., LILLEY, DAVID M.J.

Journal:

Year:

1998

File:

PDF, 559 KB

1998

45

The promise and current status of CDK12/13 inhibition for the treatment of cancer

Tadesse, Solomon, Duckett, Derek R, Monastyrskyi, Andrii

Journal:

Future Medicinal Chemistry

Year:

2020

File:

PDF, 11.28 MB

2020